Acute postinfectious glomerulonephritis

作者：Ramdani Benyounes^*; Zamd Mohamed; Hachim Khadija; Soulami Kenza; Ezzahidy Madiha; Souiri Malika; Fadili Wafaa; Lahboub Assia; Hanafi Leila; Boujida Meryem; Squalli Saida; Benkirane Amal; Benghanem Mohamed Gharbi; Medkouri Ghizlane

来源：Nephrologie & Therapeutique, 2012, 8(4): 247-258.

DOI：10.1016/j.nephro.2011.11.011

• Acute postinfectious glomerulonephritis
• Acute nephritic syndrome
• Immune complex
• Complement
• Renal biopsy
• Endocapillary proliferation
• Infection
• Streptococcus

Acute postinfectious glomerulonephritis are defined by an acute nonsuppurative inflammatory insult predominantly glomerular. Its current incidence is uncertain because of the frequency of subclinical forms. The most common infectious agent involved is beta hemolytic streptococcus group A. Acute postinfectious glomerulonephritis is uncommon in adults, and its incidence is progressively declining in developed countries. Humoral immunity plays a key role in the pathogenesis of kidney damage. Complement activation by the alternative pathway is the dominant mechanism, but a third way (lectin pathway) has been recently identified. The classic clinical presentation is sudden onset of acute nephritic syndrome after a free interval from a streptococcal infection. Treatment is essentially symptomatic and prevention is possible through improved hygiene and early treatment of infections.

• 出版日期2012-7