Association between FAS A670G polymorphism and susceptibility to cervical cancer: evidence from a meta-analysis

作者：Shen, Jian; Sun, Ning-Xia^*

来源：Tumor Biology, 2013, 34(6): 3443-3448.

DOI：10.1007/s13277-013-0920-y

• FAS
• Meta-analysis
• Polymorphism
• Cervical cancer

Previous studies published to evaluate the association between FAS A670G polymorphism and susceptibility to cervical cancer provided conflicting findings. A meta-analysis of published case-control studies was performed to get a comprehensive evidence for the possible association. We searched in PubMed and Wanfang databases for eligible studies published before February 10, 2013. The odds ratio (OR) with 95 % confidence interval (95 % CI) was used to evaluate the association. Ten studies with a total of 4,904 participants were finally included into the meta-analysis. Overall, there was no obvious association between FAS A670G polymorphism and susceptibility to cervical cancer under all four genetic models (G versus A: OR = 0.97, 95 % CI 0.84-1.11, P = 0.64; GG versus AA: OR = 0.92, 95 % CI 0.69-1.24, P = 0.60; GG/AG versus AA: OR = 0.99, 95 % CI 0.77-1.26, P = 0.92; GG versus AA/AG: OR = 0.92; 95 % CI 0.68-1.25, P = 0.59). Subgroup analyses by ethnicity further showed that there was no association between FAS A670G polymorphism and susceptibility to cervical cancer in both Caucasians and Asians. There was no risk of publication bias. In summary, the meta-analysis suggests that there is no association between FAS A670G polymorphism and susceptibility to cervical cancer in both Caucasians and Asians.

• 出版日期2013-12
• 单位上海交通大学; 上海市闵行区中心医院; 天津市中医药研究院附属医院; 中国人民解放军第二军医大学