Azide- and Alkyne-Derivatised alpha-Amino Acids

作者：Johansson Henrik; Pedersen Daniel Sejer^*

来源：European Journal of Organic Chemistry, 2012, 2012(23): 4267-4281.

DOI：10.1002/ejoc.201200496

• Amino acids
• Azides
• Alkynes
• Peptidomimetics
• Click chemistry

With the emergence of the copper-catalysed Huisgen cycloaddition the use of azide- and alkyne-derivatised a-amino acids has found widespread use within most chemistry disciplines. Despite a growing interest in these building blocks researchers are struggling to identify the best way for their synthesis. In this review we have compiled available methods for synthesising optically active azide- and alkyne-derivatised a-amino acids that can be prepared from readily available a-amino acids. We highlight a number of commonly overlooked problems associated with existing methods and direct attention to unexplored possibilities.

• 出版日期2012-8