Delta-sleep inducing peptide entrapment in the charged macroporous matrices

作者：Sukhanova Tatiana V^*; Artyukhov Alexander A; Gurevich Yakov M; Semenikhina Marina A; Prudchenko Igor A; Shtilman Mikhail I; Markvicheva Elena A

来源：Materials Science and Engineering: C , 2014, 42: 461-465.

DOI：10.1016/j.msec.2014.05.059

• Adsorption
• Biopolymers
• Drug delivery systems
• Macroporous polymers
• Delta-sleep inducing peptide

Various biomolecules, for example proteins, peptides etc., entrapped in polymer matrices, impact interactions between matrix and cells, including stimulation of cell adhesion and proliferation. Delta-sleep inducing peptide (DSIP) possesses numerous beneficial properties, including its abilities in burn treatment and neuronal protection. DSIP entrapment in two macroporous polymer matrices based on copolymer of dimethylaminoethyl methacrylate and methylen-bis-acrylamide (Co-DMAEMA-MBAA) and copolymer of acrylic acid and methylen-bis-acrylamide (Co-AA-MBAA) has been studied. Quite 100% of DSIP has been entrapped into positively charged Co-DMAEMA-MBAA matrix, while the quantity of DSIP adsorbed on negatively charged Co-AA-MBAA was only 2-6%. DSIP release from Co-DMAEMA-MBAA was observed in saline solutions (0.9% NaCl and PBS) while there was no DSIP release in water or 25% ethanol, thus ionic strength was a reason of this process.

• 出版日期2014-9-1
• 单位北京化工大学