Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

作者：Wang SC; Lien HC; Xia WY; Chen IF; Lo HW; Wang ZQ; Ali Seyed M; Lee DF; Bartholomeusz G; Fu OY; Giri DK; Hung MC^*

来源：Cancer Cell, 2004, 6(3): 251-261.

DOI：10.1016/j.ccr.2004.07.012

Pathological expression of human ErbB-2 protein, also known as HER-2, is common in many types of cancer. ErbB-2 is a member of the EGF receptor tyrosine kinase family and has been rigorously studied as a signaling molecule on the cell membrane. Here, we report that ErbB-2 is also expressed in the nucleus in cultured cells as well as primary tumor tissues. Nuclear ErbB-2 was found to associate with multiple genomic targets in vivo, including the cyclooxygenase enzyme COX-2 gene promoter. ErbB-2 forms a complex at a specific nucleotide sequence of the COX-2 promoter and is able to stimulate its transcription. This study demonstrates the presence of ErbB-2 in the nucleus and identifies the function of ErbB-2 as a transcriptional regulator.

• 出版日期2004-9