科研之友
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摘要
The foreign body reactions are commonly referred to a network of immune and inflammatory reactions of human or animals in response to foreign objects being placed in tissues. They are basic biological processes, and are also highly relevant to bioengineering applications in implants, as fibrotic tissue formations surrounding medical implants have been found to substantially reduce the effectiveness of devices. Despite the intensive research on determining the mechanisms governing such complex responses, few mechanistic mathematical models have been developed to study such foreign body reactions. This study focuses on a kinetics-based predictive tool to analyse the outcomes of multiple interactive complex reactions of various cells/proteins and biochemical processes and to understand transient behaviour during the entire period (up to several months). A computational model in two spatial dimensions is constructed to investigate the time dynamics as well as the spatial variation of foreign body reaction kinetics. The simulation results have been consistent with the experimental data and the model can facilitate quantitative insights into the study of foreign body reaction process, in general.
- 出版日期2011
