An efficient ultrasound-promoted method for the synthesis of bis(indole) derivatives

作者：Rahimi Somayeh; Amrollahi Mohammad A^*; Kheilkordi Zohreh

来源：Comptes Rendus Chimie, 2015, 18(5): 558-563.

DOI：10.1016/j.crci.2014.10.005

• Aqueous media
• Bis(indole)
• Heteropolyacids
• Michael reactions
• Oxidative dehydrogenation
• Ultrasonication

In this paper, the reaction of indole with electron-deficient alkenes in aqueous media is reported. This procedure allows the synthesis of bis(indole) derivatives in good to high yields at 90 degrees C under silent and ultrasound irradiation conditions. Short reaction times and high yields of desired products are the main advantages of the presented procedure. This reaction catalyzed by 12-tungstophosphoric acid is operationally simple and considers environmental aspects by avoiding toxic catalysts and solvents.

• 出版日期2015-5