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摘要
To investigate hepatosplenic volumetry at MDCT for non-invasive prediction of hepatic fibrosis. Hepatosplenic volume analysis in 624 patients (mean age, 48.8 years; 311 M/313 F) at MDCT was performed using dedicated software and compared against pathological fibrosis stage (F0 = 374; F1 = 48; F2 = 40; F3 = 65; F4 = 97). The liver segmental volume ratio (LSVR) was defined by Couinaud segments I-III over segments IV-VIII. All pre-cirrhotic fibrosis stages (METAVIR F1-F3) were based on liver biopsy within 1 year of MDCT. LSVR and total splenic volumes increased with stage of fibrosis, with mean(+/- SD) values of: F0: 0.26 +/- 0.06 and 215.1 +/- 88.5 mm(3); F1: 0.25 +/- 0.08 and 294.8 +/- 153.4 mm(3); F2: 0.331 +/- 0.12 and 291.6 +/- 197.1 mm(3); F3: 0.39 +/- 0.15 and 509.6 +/- 402.6 mm(3); F4: 0.56 +/- 0.30 and 790.7 +/- 450.3 mm(3), respectively. Total hepatic volumes showed poor discrimination (F0: 1674 +/- 320 mm(3); F4: 1631 +/- 691 mm(3)). For discriminating advanced fibrosis (ae<yen>F3), the ROC AUC values for LSVR, total liver volume, splenic volume and LSVR/spleen combined were 0.863, 0.506, 0.890 and 0.947, respectively. Relative changes in segmental liver volumes and total splenic volume allow for non-invasive staging of hepatic fibrosis, whereas total liver volume is a poor predictor. Unlike liver biopsy or elastography, these CT volumetric biomarkers can be obtained retrospectively on routine scans obtained for other indications. aEuro cent Regional changes in hepatic volume (LSVR) correlate well with degree of fibrosis. aEuro cent Total liver volume is a very poor predictor of underlying fibrosis. aEuro cent Total splenic volume is associated with the degree of hepatic fibrosis. aEuro cent Hepatosplenic volume assessment is comparable to elastography for staging fibrosis. aEuro cent Unlike elastography, volumetric analysis can be performed retrospectively.
- 出版日期2017-7
