Make microspheres through emulsion-solvent evaporation method

作者：Shao Wen Yao^*; He Cai Yun; Feng Yan Ling; Chen Yu Qing

来源：Journal of Functional Materials, 2015, 46(3): 03121-03126.

DOI：10.3969/j.issn.1001-9731.2015.03.026

• Emulsion solvents
• Emulsion-solvent evaporation method
• Encapsulation efficiency
• Optimal conditions
• Phase volume ratio
• Poly lactic acid
• Technical conditions
• Vitamin A

In this study, o/w emulsion-solvent evaporation method was used to make microspheres, using dichloromethane as the solvent phase, polylactic acid as the carrier material and vitamin A acid as the entrapped object, tween 80 and gelatine as emulsifier. The technical conditions such as shear speed, shear time, internal, external phase volume ratio and the amount of wall material were determined. The experiments demonstrated that the optimal conditions were: gelatin concentration of 7.5 mg/mL, tween concentration of 6 mg/mL, polylactic acid concentration of 10 mg/mL, inside and outside the phase volume ratio of 1:10, shearing time of 30 min, stirring speed of 300 r/min, volatile time of 3 h. The final product was smooth and well dispersed, and the encapsulation efficiency was 52.42%.

• 出版日期2015
• 单位厦门大学