Disease measurement - enthesitis, skin, nails, spine and dactylitis

作者：Coates Laura C; Helliwell Philip S^*

来源：Best Practice & Research in Clinical Rheumatology, 2010, 24(5): 659-670.

DOI：10.1016/j.berh.2010.05.004

• spondyloarthropathy
• skin
• nail
• enthesis
• dactylitis
• outcome measures
• clinical assessment

Outcome measurement is a key part of study design but presents particular challenges in spondyloarthropathy Enthesitis and dactylitis are typical features of spondyloarthropathy and validated scoring systems for both are available although the majority of enthesitis outcome measures are validated in ankylosing spondylitis (AS) only Assessment of axial disease is well researched in AS and composite outcome measures are routinely used However assessment of axial disease in predominantly peripheral arthritis such as psoriatic arthritis is problematic and under-researched Extensive research in dermatology has provided multiple outcome measures for skin psoriasis The psoriasis area and severity Index (PASI) remains the most common outcome measure used despite the fact that significant problems exist with this scale and that newer scorin

• 出版日期2010-10