Acute invasive fungal rhinosinusitis: MR imaging features and their impact on prognosis

作者：Choi Ye Ra; Kim Ji hoon^*; Min Hye Sook; Won Jae Kyung; Kim Hyun Jik; Yoo Roh Eul; Kang Koung Mi; Park Sun Won; Yun Tae Jin; Choi Seung Hong; Sohn Chul Ho; Rhim Jung Hyo; Kim Soo Chin; Ryu Jae Wook; Na Dong Gyu

来源：Neuroradiology, 2018, 60(7): 715-723.

DOI：10.1007/s00234-018-2034-0

• Acute invasive fungal rhinosinusitis
• Lack of contrast enhancement
• Magnetic resonance imaging
• Coagulative necrosis
• Prognosis

Acute invasive fungal rhinosinusitis (AIFRS) is a life-threatening disease that is difficult to diagnose. Its overall imaging features have not been evaluated and the prognostic impact is unclear. The purpose of our study was to present MR imaging features and their impact on prognosis of AIFRS.
MR images and clinical records of 23 patients with AIFRS were retrospectively evaluated to identify the imaging features and to determine the factors affecting patients' survival. A multivariable Cox proportional hazard model was used to estimate the hazard ratio of the prognostic factors, and Kaplan-Meier survival curves were compared by using a log-rank test.
All cases showed extra-sinonasal involvement and the orbit was the most common (65.2%, 15/23) location. The lesion enhancement pattern was classified into lack of contrast enhancement (LoCE) (47.8%, 11/23) and homogeneous (34.8%, 8/23) and heterogeneous (17.4%, 4/23) enhancement. Although LoCE showed variable signal intensity (SI), homogeneously or heterogeneously enhancing lesions showed exclusively low SI (100%, 12/12) on T2WI. Among various clinical and imaging factors, LoCE was correlated with coagulation necrosis, probably provoked by numerous fungal hyphae, and was found to be a sole independent prognostic factor for disease-specific mortality (hazard ratio = 16.819; 95% CI, 1.646-171.841, p = 0.017). In addition, patients with LoCE showed worse survival than patients without LoCE (p = 0.008).
AIFRS showed frequent extra-sinonasal involvement and variable MR enhancement patterns. An enhancement pattern of LoCE was seen in about half of the cases and was a unique prognostic factor among the various clinico-radiologic factors.

• 出版日期2018-7