A novel prenylated C-6-C-3 compound with estrogen-like activity from the fruits of Illicium arborescens

作者：Liaw Chia Ching; Chen Yu Chen; Fazary Ahmed Eid; Hsieh Ju Liang; Chen Shun Ying; Chien Ching Te; Sheu Shiow Yunn; Kuo Yao Haur; Chiang Bor Luen; Shen Ya Ching^*

来源：Phytochemistry Letters, 2013, 6(3): 397-402.

DOI：10.1016/j.phytol.2013.04.005

• Illicium arborescens
• Prenylated C-6-C-3 compounds
• Illicarborene A
• Estrogen-like activity
• Cytotoxicity

A novel C-6-C-3 prenylated compound, illicarborene A (1), together with illioliganfunone D (2), 1-allyl-3,5-dimethoxy-4-(3-methylbut-2-enyloxy)benzene (3), (-)-illicinone A (4), (-)-illicinone B (5) and (-)-illicinone A derivative (6) was isolated and characterized from the fruits of Illicium arborescens Hayata. Compound 1 possesses a new class of tricyclic 6/6/5 ring system. The structure of 1 was determined by spectroscopic analysis such as H-1-H-1 COSY, HMQC, HMBC, and NOESY, and confirmed by chemical reaction to yield 7. Compounds 1-5 were found to increase proliferative activity in primary cell culture of osteoblast cells.

• 出版日期2013-8