Dynamics of hepatitis B virus resistance to entecavir in a nucleoside/nucleotide-naive patient

作者：Guo Jin Jun; Li Qing Ling; Shi Xiao Feng; Zhang Da Zhi; Zeng Ai Zhong; Feng Tao; Huang Ai Long^*

来源：Antiviral Research, 2009, 81(2): 180-183.

DOI：10.1016/j.antiviral.2008.09.004

• Hepatitis B virus
• Entecavir
• Antiviral therapy
• Drug resistance
• Quasi-species evolution

The genotypic evolution of HBV quasi-species was analyzed in a nucleoside/nucleotide-naive patient who developed resistance to entecavir. The lamivudine resistant quasi-species (rtM204V /- rtL180M), absent at baseline, were emerged as early as 48 weeks after entecavir administration. Entecavir-resistant quasi-species (rtM204V /- rtL180M plus S202G) were found after week 112 and gradually became the predominant mutations afterwards. The lamivudine- and entecavir-resistant mutations emerged closely in combination with the rtV207L, rtA222T, rtP237T or rtI163V substitutions. Our results indicated that the lamivudine-resistant mutations were developed first and may serve as a prequisite for subsequent entecavir-resistant mutations in this nucleoside/nucleotide-naive patient.

• 出版日期2009-2
• 单位重庆医科大学