A highly efficient group-assisted purification method for the synthesis of poly-functionalized pyrimidin-5-yl-pyrroles via one-pot four-component domino reaction

作者：Dommaraju Yuvaraj; Prajapati Dipak^*

来源：Molecular Diversity, 2015, 19(1): 173-187.

DOI：10.1007/s11030-014-9547-1

• Multicomponent reactions
• Pyrrole
• Pyrimidine
• Chromatography
• GAP chemistry
• Green
• sustainable chemistry
• MCRs

A highly efficient, catalyst-free group-assisted purification chemical protocol for the construction of pyrimidine containing poly-functionalized pyrroles from a four-component domino reaction of acyclic-1,3-dicarbonyls or electron deficient alkynes, aromatic amines, barbituric acid and arylglyoxal hydrates under mild reaction conditions has been developed. The prominent features of the present protocol are environmentally benign, mild reaction conditions, atom economy, no column chromatography separation, easy isolation of products and excellent yields.

• 出版日期2015-2