Analysis of tumor populations in non-small-cell lung cancer with FDG-PET according to pathological and genetic criteria

作者：El Yaagoubi Y; Perraudeau F; Barre I; Guillet J; Momboisse D; Role C; Bernard O; Cauchois A; Colin J; Fagot T; Nguyen L^*

来源：Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique, 2015, 39(2): 165-172.

DOI：10.1016/j.mednuc.2014.09.005

• FDG-PET
• Lung cancer
• Pathology
• K-ras
• Epidermal growth factor receptor (EGFR)

Purpose. - To investigate the relationship between the maximum standardized uptake value (SUVmax) on FDG-PET and pathological type, and K-ras/EGFR mutations status in non-small-cell lung cancer (NSCLC).
Patients and methods. - We made a retrospective review of 123 patients with pathologically proven NSCLC who underwent FDG-PET before treatment. Pathological type was determined and in case of adenocarcinomas, K-ras and EGFR mutations were searched. Comparisons of SUVmax were realized on the one hand between pathological type groups' squamous cell carcinoma (SCC) and adenocarcinoma (AC) and on the other hand between groups depending on the K-ras or EGFR mutations status.
Results. - Ninety-one AC and 32 SCC were diagnosed. K-ras and EGFR mutations were respectively found in 31 and 30 cases. Using a Mann-Whitney test, SUVmax was significantly different between pathological type groups. SUVmax of the SCC group was higher than that of AC group (P = 0.01). No difference was found between SUVmax and K-ras mutant vs. wild types (P = 0.70) nor EGFR mutant vs. wild types (P = 0.20).
Conclusion. - SUVmax was higher in SCC compared to AC, suggesting a greater aggressiveness for this histological type. There was no difference between SUVmax considering neither the K-ras nor the EGFR status.

• 出版日期2015-4