A new cytotoxic tambjamine alkaloid from the Azorean nudibranch Tambja ceutae

作者：Carbone Marianna; Irace Carlo; Costagliola Francesca; Castelluccio Francesco; Villani Guido; Calado Goncalo; Padula Vinicius; Cimino Guido; Cervera J Lucas; Santamaria Rita; Gavagnin Margherita^*

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(8): 2668-2670.

DOI：10.1016/j.bmcl.2010.02.020

• Marine natural products
• Bromopyrrole alkaloids
• Spectroscopic methods
• Cytotoxic activity

The chemical investigation of Azorean nudibranch mollusk Tambja ceutae led us to isolate a new member of the tambjamine family, tambjamine K (1). The bryozoan Bugula dentata, prey of the nudibranch, was also analyzed and found to contain compound 1 in very small amounts together with known blue pigment 2 and tambjamines A (3) and B (4). The structure of tambjamine 1 was elucidated by the interpretation of the spectroscopic data as well as by the comparison with related compounds. Compounds 1 and 2 possess antiproliferative activity, in particular, tambjamine K (1) displayed high cytotoxicity against both tumor and non-tumor mammalian cells.

• 出版日期2010-4-15