Antibacterial Properties of Bioactive Ti in Vivo and Its Mechanism

作者：Zhang Demao; Zou Wen; Zhang Qiyi; Yang Bangcheng^*

来源：Rare Metal Materials and Engineering, 2013, 42(7): 1483-1487.

• titanium
• bioactivity
• protein
• antibacterial property

In order to study the antibacterial properties of bioactive Ti and its mechanism, alkali-heat treated titanium (AR-Ti) was implanted in rat with Staphylococcus aureus suspension to make infection with pure titanium as contrast. The myeloperoxidase activity was detected for evaluating the rat's inflammation. The concentrations of albumin and fibrinogen were measured by the Enzymemultiplied immunoassay technique. The results show the AH-Ti related inflammation is low along with low albumin and fibrinogen. It is proved AR-Ti has good antibacterial property in vivo. The mechanism for AH-Ti to prevent bacteria adhering to its surface is that its selectively absorbing albumin to its surface weakens the inflammation around the AR-Ti, and the fibrinogen concentration is lower in turn.

• 出版日期2013-7
• 单位四川大学