A solid- and solution-phase-based library of 2 beta-methyl substituted penicillin derivatives and their effects on growth inhibition of tumor cell lines

作者：Boggian Dora B; Cornier Patricia G; Mata Ernesto G^*; Blank Viviana C; Cardenas Mariano G; Roguin Leonor P

来源：Medchemcomm, 2015, 6(4): 619-625.

DOI：10.1039/c4md00430b

We described the design, synthesis and antiproliferative properties of a series of twenty 2 beta-methyl substituted penicillin derivatives. This analysis includes evaluation against HeLa and MCF-7 human tumor cell lines and LM3 and B16-F0 murine tumor cell lines. The epithelial cell line derived from the normal mammary gland of mice (NMuMG) and the mouse embryo fibroblast cell line (3T3) were used as controls (non-cancer cells).

• 出版日期2015