Association between Postmenopausal Osteoporosis and Experimental Periodontitis

作者：Luo, Kai; Ma, Souzhi; Guo, Jianbin; Huang, Yongling; Yan, Fuhua^*; Xiao, Yin

来源：Biomed Research International, 2014, 2014: 316134.

DOI：10.1155/2014/316134

• GINGIVAL CREVICULAR FLUID
• COLONY-STIMULATING FACTOR
• ALVEOLAR BONE LOSS
• RECEPTOR ACTIVATOR
• OSTEOCLAST DIFFERENTIATION
• OSTEOPROTEGERIN LIGAND
• GENE POLYMORPHISMS
• MINERAL DENSITY
• CYTOKINES
• INTERLEUKIN-10

To investigate the correlation between postmenopausal osteoporosis (PMO) and the pathogenesis of periodontitis, ovariectomized rats were generated and the experimental periodontitis was induced using a silk ligature. The inflammatory factors and bone metabolic markers were measured in the serum and periodontal tissues of ovariectomized rats using an automatic chemistry analyzer, enzyme-linked immunosorbent assays, and immunohistochemistry. The bone mineral density of whole body, pelvis, and spine was analyzed using dual-energy X-ray absorptiometry and image analysis. All data were analyzed using SPSS 13.0 statistical software. It was found that ovariectomy could upregulate the expression of interleukin-(IL-)6, the receptor activator of nuclear factor-kappa B ligand (RANKL), and osteoprotegerin (OPG) and downregulate IL-10 expression in periodontal tissues, which resulted in progressive alveolar bone loss in experimental periodontitis. This study indicates that changes of cytokines and bone turnover markers in the periodontal tissues of ovariectomized rats contribute to the damage of periodontal tissues.

• 出版日期2014
• 单位南京大学; 福建医科大学