An improved synthesis of (-)-martinellic acid via radical addition - Cyclization-elimination reaction of chiral oxime ether

作者：Miyata O; Shirai A; Yoshino S; Takeda Y; Sugiura M; Naito T^*

来源：Synlett, 2006, (6): 893-896.

DOI：10.1055/s-2006-939046

• martinellic acid
• radical reaction
• oxime ether
• asymmetric synthesis
• pyrroloquinoline

A concise formal synthesis of (-)-martinellic acid has been accomplished by preparing optically active dipyrroloquinoline as a key synthetic intermediate, which was prepared via the radical addition-cyclization-elimination of oxime ether carrying all unsaturated ester followed by two chemoselective reductions of the carbonyl groups.

• 出版日期2006-4-4