Non-enzymatic detection of hydrogen peroxide using a functionalized three-dimensional graphene electrode

作者：Xi Fengna^*; Zhao Dongjiao; Wang Xuewan; Chen Peng

来源：Electrochemistry Communications, 2013, 26: 81-84.

DOI：10.1016/j.elecom.2012.10.017

• 3D graphene
• Electrochemical sensing
• Hydrogen peroxide
• Thionine
• Polydopamine

A novel three-dimensional (3D) electrochemical sensor was developed for highly sensitive detection of hydrogen peroxide (H2O2). Monolithic and macroporous graphene foam grown by chemical vapor deposition (CVD) served as the electrode scaffold. Using in-situ polymerized polydopamine as the linker, the 3D electrode was functionalized with thionine molecules which can efficiently mediate the reduction of H2O2 at close proximity to the electrode surface. Such stable non-enzymatic sensor is able to detect H2O2 with a wide linear range (0.4 to 660 mu M), high sensitivity (169.7 mu A mM(-1)), low detection limit (80 nM), and fast response (reaching 95% of the steady current within 3 s). Furthermore, this sensor was used for real-time detection of dynamic release of H2O2 from live cancer cells in response to a pro-inflammatory stimulant.

• 出版日期2013-1
• 单位浙江理工大学; 南阳理工学院