Adult human dental pulp stem cells promote blood-brain barrier permeability through vascular endothelial growth factor-a expression

作者：Winderlich Joshua N; Kremer Karlea L; Koblar Simon A^*

来源：Journal of Cerebral Blood Flow and Metabolism, 2016, 36(6): 1087-1097.

DOI：10.1177/0271678X15608392

• Dental pulp stem cells
• blood-brain barrier
• vascular endothelial growth factor
• stromal-derived factor 1
• in vitro

Stem cell therapy is a promising new treatment option for stroke. Intravascular administration of stem cells is a valid approach as stem cells have been shown to transmigrate the blood-brain barrier. The mechanism that causes this effect has not yet been elucidated. We hypothesized that stem cells would mediate localized discontinuities in the blood-brain barrier, which would allow passage into the brain parenchyma. Here, we demonstrate that adult human dental pulp stem cells express a soluble factor that increases permeability across an in vitro model of the blood-brain barrier. This effect was shown to be the result of vascular endothelial growth factor-a. The effect could be amplified by exposing dental pulp stem cell to stromal-derived factor 1, which stimulates vascular endothelial growth factor-a expression. These findings support the use of dental pulp stem cell in therapy for stroke.

• 出版日期2016-6