Antiobesity Effects of Bifidobacterium breve Strain B-3 Supplementation in a Mouse Model with High-Fat Diet-Induced Obesity

作者：Kondo Shizuki; Xiao Jin zhong^*; Satoh Takumi; Odamaki Toshitaka; Takahashi Sachiko; Sugahara Hirosuke; Yaeshima Tomoko; Iwatsuki Keiji; Kamei Asuka; Abe Keiko

来源：Bioscience Biotechnology and Biochemistry, 2010, 74(8): 1656-1661.

DOI：10.1271/bbb.100267

• Bifidobacterium breve
• antiobesity
• insulin
• microbiota
• proglucagon

The aim of the present study was to evaluate the antiobesity activity of a probiotic bifidobacterial strain in a mouse model with obesity induced by a high-fat diet. The mice were fed a high-fat diet supplemented with Bifidobacterium breve B-3 at 10(8) or 10(9) CFU/d for 8 weeks. B. breve B-3 supplementation dose-dependently suppressed the accumulation of body weight and epididymal fat, and improved the serum levels of total cholesterol, fasting glucose and insulin. The bifidobacterial counts in the caecal contents and feces were significantly increased with the B. breve B-3 administration. The expression of genes related to fat metabolism and insulin sensitivity in the gut and epididymal fat tissue was up-regulated by this administration. These results suggest that the use of B. breve B-3 would be effective in reducing the risk of obesity.

• 出版日期2010-8