aPKC lambda/iota is a beneficial prognostic marker for pancreatic neoplasms

作者：Kato Shingo; Akimoto Kazunori; Nagashima Yoji; Ishiguro Hitoshi; Kubota Kensuke; Kobayashi Noritoshi; Hosono Kunihiro; Watanabe Seitaro; Sekino Yusuke; Sato Takamitsu; Sasaki Kazunori; Nakaigawa Noboru; Kubota Yoshinobu; Inayama Yoshiaki; Endo Itaru; Ohno Shigeo; Maeda Shin; Nakajima Atsushi^*

来源：Pancreatology, 2013, 13(4): 360-368.

DOI：10.1016/j.pan.2013.05.006

• Atypical protein kinase C lambda/iota
• Pancreatic ductal adenocarcinoma
• Intraductal papillary mucinous neoplasms

Pancreatic cancer is a lethal disease. Overall survival is typically 6 months from diagnosis. Determination of prognostic factors in pancreatic cancer that would allow identification of patients who could potentially benefit from aggressive treatment is important. However, until date, there are no established reliable prognostic factors for pancreatic cancer patients. Herein, we propose a beneficial biomarker which is significantly correlated with the prognosis in pancreatic cancer patients. Atypical protein kinase C lambda/iota (aPC lambda/iota is overexpressed and has been implicated in the progression of several cancers. We tested the expression levels of aPKC lambda/iota in two types of pancreatic neoplasm, pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasms (IPMNs), by immunohistochemistry. Examination of the aPKC lambda/iota expression levels in surgically resected specimens of PDCA (n = 115) demonstrated that the expression levels of aPKC lambda/iota in PDAC had prognostic implications, independent of the Tumor-Node-Metastasis classification and World Health Organization tumor grade. In the case of IPMNs (n = 46) also, the expression levels of aPKC lambda/iota in IPMN were found to be of prognostic importance, independent of the World Health Organization histological grade or morphological type. Interestingly, high expression levels of aPKC lambda/iota were significantly correlated with a worse histological grade (p = 0.010) and advanced stage of the tumor (p = 0.0050) in IPMN patients. These findings suggest that high expression levels of aPKC lambda/iota could be involved in the malignant transformation of IPMNs. Based on these observations, we propose the expression level of aPKC lambda/iota as a prognostic marker common to different types of pancreatic neoplasms.

• 出版日期2013-8