Direct amidation of aniline derivatives with 1,1-dichloro-2-nitroethene in water

作者：Zhu, Fengjuan; Tian, Xue; Shao, Xusheng^*; Li, Zhong

来源：Tetrahedron Letters, 2015, 56(43): 5945-5949.

DOI：10.1016/j.tetlet.2015.09.048

• Green methodology
• Direct amidation
• 1,1-Dichloro-2-nitroethene
• N-nitroacetylation

A green methodology was established for direct amidation of anilines using 1,1-dichloro-2-nitroethene. The new protocol provides convenient N-nitroacetylation for the anilines. This method was applicable to anilines include anthranilic acids, anthranilamides, phenylbenzohydrazides, diphenylamine, and 2-aminobenzenesulfonamide. The amidation process was accomplished in water and the products can be easily separated by filtration.

• 出版日期2015-10-21
• 单位华东理工大学