An Efficient One-Pot Copper-Catalyzed Approach to Isoquinolin-1(2H)-one Derivatives

作者：Wang, Feng; Liu, Hongxia; Fu, Hua^*; Jiang, Yuyang; Zhao, Yufen

来源：Organic Letters, 2009, 11(11): 2469-2472.

DOI：10.1021/ol900847t

A simple and efficient copper-catalyzed method for synthesis of 3,4-disubstituted isoquinolin-1(2H)-one derivatives via cascade reactions of substituted 2-halobenzamides with beta-keto esters under mild conditions has been developed, and the method has economical and practical advantages.

• 出版日期2009-6-4
• 单位清华大学