Preparation and Reactions of 2-Methyl-7-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-5-arylthiazolo[3,2 -a]-pyrimido[4,5-d]oxazin-4(5H)-one

作者：Youssef Mohamed Salah K^*; Abbady Mohamed S; Ahmed Ragaa A; Omar Ahmed A

来源：Chinese Journal of Chemistry, 2011, 29(7): 1473-1482.

DOI：10.1002/cjoc.201180268

• thiazolopyrimidooxazinone
• thiazolopyrimidopyrimidines
• antimicrobial activity

Ethyl 7-amino-3-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-5-aryl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate was hydrolyzed with an ethanolic sodium hydroxide and the sodium salt thus formed underwent cyclization with acetic anhydride to afford 2-methyl-7-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-5-arylthiazolo[3,2-a]-pyrimido[4,5-d]oxazin-4(5H)-one. This compound was transformed to related heterocyclic systems via its reaction with various reagents. The biological activity of the prepared compounds was tested against Gram positive and Gram negative bacteria as well as yeast-like and filamentous fungi. They revealed in some cases excellent biocidal properties.

• 出版日期2011-7