Pulmonary alveolar proteinosis in a kidney transplant: a rare complication of sirolimus

作者：Kadikoy Huseyin^*; Paolini Michael; Achkar Katafan; Suki Wadi; Gaber A Osama; Anwar Nabeel; Jeroudi Abdallah; Barrios Roberto; Abdellatif Abdul

来源：Nephrology Dialysis Transplantation, 2010, 25(8): 2795-2798.

DOI：10.1093/ndt/gfq265

• haemolytic uraemic syndrome
• kidney transplant
• pulmonary alveolar proteinosis
• sirolimus
• tacrolimus

Pulmonary alveolar proteinosis (PAP) has been associated with the immunosuppressant sirolimus in transplant patients. PAP is a progressive lung disease characterized by the accumulation of surfactant-like material in the lungs leading to decreased pulmonary function with shortness of breath and cough as common symptoms. We report a rare case of sirolimus-associated PAP in a kidney transplant recipient with a history of end-stage renal disease secondary to haemolytic uraemic syndrome (HUS) and review of the literature. Discontinuation of sirolimus and initiation of tacrolimus led to resolution of PAP without recurrence of HUS.

• 出版日期2010-8