Azaindole synthesis through dual activation catalysis with N-heterocyclic carbenes

作者：Sharma Hayden A; Hovey M Todd; Scheidt Karl A^*

来源：Chemical Communications, 2016, 52(59): 9283-9286.

DOI：10.1039/c6cc04735a

A convergent, transition-metal-free synthesis of 2-aryl-azaindoles has been developed. The interception of a reactive aza-ortho-azaquinone methide intermediate by an acyl anion equivalent generated through carbene catalysis provides high yields, a wide substrate scope, and the synthesis of previously inaccessible azaindoles.

• 出版日期2016
• 单位西北大学