Direct carboxylation of aromatic compounds using the sodium hydrogen carbonate/triphenylphosphine ditriflate system

作者：Khodaei Mohammad M; Alizadeh Abdolhamid^*; Hezarkhani Hadis A

来源：Comptes Rendus Chimie, 2018, 21(1): 27-31.

DOI：10.1016/j.crci.2017.10.008

• Triphenylphosphine ditriflate
• Carboxylic acids
• Arenes
• Sodium hydrogen carbonate
• Electrophilic substitution

A new procedure was developed for the highly regioselective synthesis of aromatic carboxylic acids using the sodium hydrogen carbonate/triphenylphosphine ditriflate system in ethanol at room temperature. This metal-free system was used for the carboxylation of thiophenol with unexpected products in terms of selectivity. The simplicity of the procedure, readily available aromatic compounds, short reaction times, and mild reaction conditions are other advantages of this protocol.

• 出版日期2018-1