科研之友
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摘要
Objective Variants of adiponectin gene have been reported to be associated with coronary heart disease (CHD), but the available data on this relationship are inconsistent. A meta-analysis was performed to quantitatively analyse the association of adiponectin gene polymorphisms with coronary artery disease using previous casecontrol studies in Chinese Han populations. @@@ Methods Several electronic databases were searched for relevant articles up to January 2011. After data collection and gene loci selection, a meta-analysis was performed to assess heterogeneity, combine results and evaluate variations. Publication bias was examined by the Egger's linear regression test. Hardy-Weinberg equilibrium (HWE) test and by omitting one study at a time was employed for the sensitivity analysis. @@@ Results Eleven studies covering 4303 subjects focusing on two polymorphisms [+ 45T -> G (rs2241766) and + 276G -> T (rs1501299)] in the adiponectin gene and risk of CHD were included in the meta-analysis. Combined analyses of studies of the SNP+ 45 showed no significant overall association with CHD, yielding ORs of 1 03 (0 80, 1 34) and 1 32 (0 86, 2 03) under a dominant and recessive model, respectively, with strong evidence of heterogeneity. Similar results were also obtained in other genetic models. Concerning SNP+ 276, a significantly decreased CHD risk was observed under a dominant model, a codominant model and a allele contrast model, with an odds ratio of 0 67 (0 54, 0 83), 0 77 (0 62, 0 94) and 0 69 (0 55, 0 86), respectively. Sensitivity analysis confirmed the reliability and stability of this meta-analysis. @@@ Conclusions The accumulated evidence suggested that the adiponectin gene polymorphism, SNP+ 45, is not associated with CHD, but the SNP+ 276T allele might be associated with decreased risk of CHD in the Chinese Han population. More well-designed large studies are required for the validation of this association.
- 出版日期2012-3
- 单位同济大学
