A photochemical approach for controlled drug release in targeted drug delivery

作者：Choi Seok Ki^*; Verma Manisha; Silpe Justin; Moody Ryan E; Tang Kenny; Hanson Jeffrey J; Baker James R Jr

来源：Bioorganic & Medicinal Chemistry, 2012, 20(3): 1281-1290.

DOI：10.1016/j.bmc.2011.12.020

• o-Nitrobenzyl linker
• Photocleavage
• Methotrexate
• Dendrimer
• Controlled release
• Drug delivery

Photochemistry provides a unique mechanism that enables the active control of drug release in cancer-targeting drug delivery. This study investigates the light-mediated release of methotrexate, an anticancer drug, using a photocleavable linker strategy based on o-nitrobenzyl protection. We evaluated two types of the o-nitrobenzyl-linked methotrexate for the drug release study and further extended the study to a fifth-generation poly(amidoamine) dendrimer carrier covalently conjugated with methotrexate via the onitrobenzyl linker. We performed the drug release studies by using a combination of three standard analytical methods that include UV/vis spectrometry, (1)H NMR spectroscopy, and anal. HPLC. This article reports that methotrexate is released by the photochemical mechanism in an actively controlled manner. The rate of the drug release varies in response to multiple control parameters, including linker design, light wavelength, exposure time, and the pH of the medium where the drug release occurs.

• 出版日期2012-2-1
• 单位河北医科大学