Application value of ADC in the diagnosis of lipid-containing small hepatocellular carcinoma with different histopathologic grades

作者：Lei, Jing; An, Weimin^*; Dong, Jinghui; Liu, Changchun

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(7): 10548-+.

• Lipid-containing small HCC
• apparent diffusion coefficient (ADC)
• diffusion weighted imaging (DWI)
• pathological grade

This study aimed to explore the application value of ADC on DWI imaging in the diagnosis of lipid-containing small hepatocellular carcinoma (HCC) with different histopathologic grades and the correlation of ADC with histopathologic differentiation. Retrospective analysis included 78 cases of hepatocellular lesions of lipid-containing small HCC, which were confirmed by pathological examination, were retrospectively reviewed, and all patients underwent preoperative MR, including conventional scanning DWI sequence and dual-echo in-phrase and opposed-phrase sequence. Then they were divided into well-differentiated group, moderately differentiated group, and poorly differentiated group according to pathologic results after surgery, following measurement of the ADC values of preoperative lesions in the three groups respectively. Statistical analysis was performed by using SPSS 17.0. Quantitative data of single group with normal distribution and homogeneity of variance was performed by analysis of variance (ANOVA). Independent samples t-test was applied to pairwise comparisons, while Spearman rank correlation analysis was used to assess the correlation of ADC values with HCC differentiation. The results of ADC measurement revealed that the mean ADC value of lipid-containing small HCC in the poorly differentiated group, moderately differentiated group, and well-differentiated group was approximately (0.96 +/- 0.03) x10(-3) mm/s, (1.14 +/- 0.09) x10(-3) mm/s, (1.43 +/- 0.04) x10(-3) mm/s, respectively. There was significant difference between poorly differentiated group and moderately differentiated group, as well as between poorly differentiated group and well-differentiated group (P < 0.05), while there was no significant difference between well-differentiated group and moderately differentiated group (P > 0.05). Meanwhile, there was moderately positive correlation between ADC value and pathological grade of lipid-containing small HCC (P=0.002, r=0.419) and the relevant coefficient was 0.95. Taken together, ADC value can distinguish different pathological grades of lipid-containing small HCC, and there is moderately positive correlation between ADC value and pathological grade.

• 出版日期2017
• 单位中国人民解放军第三０二医院