A mild and versatile approach for DNA encapsulation

作者：Dimitrov Ivaylo V^*; Petrova Elisaveta B; Kozarova Rahila G; Apostolova Margarita D; Tsvetanov Christo B

来源：Soft Matter, 2011, 7(18): 8002-8004.

DOI：10.1039/c1sm05805c

The complex between polycation-containing thermally sensitive block copolymer and DNA (polyplex) was stabilized utilizing a seeded radical copolymerization in aqueous media under mild conditions. Thus, the DNA molecule was encapsulated into the core of a stable nanoparticle with a cross-linked polymer shell and size of similar to 100 nm. The versatility of the proposed approach was demonstrated through the introduction of targeting and biodegradable functions during the polymer shell formation providing an opportunity to construct gene carriers that are able to satisfy the conflicting requirements of adequate DNA protection and efficient release into the target cell.

• 出版日期2011