New Dogs in the Dogma: Lrp4 and Tid1 in Neuromuscular Synapse Formation

作者：Song Yuanquan; Balice Gordon Rita^*

来源：Neuron, 2008, 60(4): 526-528.

DOI：10.1016/j.neuron.2008.11.003

Two recent papers reported identification of a long-sought agrin coreceptor, Lrp4 (Kim et al. in Cell and Zhang et al. in Neuron). In this issue of Neuron, Linnoila et al. report the identification of a new player in the agrin-MuSK pathway, Tid1, which directly interacts with MuSK and is responsible for transducing signals from MuSK activation to AChR clustering, culminating in cross-linking to the subsynaptic cytoskeleton. These papers substantially reshape the agrin-MuSK-ACh hypothesis of neuromuscular synaptogenesis.

• 出版日期2008-11-26