Noncovalent interaction of 5,10,15,20-tetrakis(4-N-methylpyridyl)porphyrin with cucurbit[7]uril: A supramolecular architecture

作者：Mohanty Jyotirmayee^*; Bhasikuttan Achikanath C; Choudhury Sharmistha Dutta; Pal Haridas

来源：Journal of Physical Chemistry B, 2008, 112(35): 10782-10785.

DOI：10.1021/jp806012t

Noncovalent interaction of two water-soluble synthetic macromolecules, Cucurbit[7]uril (CB7) and 5,10,15,20-tetrakis(4-N-methylpyridyl)porphyrin (TMPyP), has been studied from the viewpoint of organizing them through supramolecular interactions and thereby modulating their functional activities. Steady-state and time-resolved fluorescence measurements along with NMR results establish that CB7 crowns the N-methylpyridyl group of the TMPyP in a 1:4 stoichiometry. The overall binding constant was evaluated to be similar to 4.5 x 10(19) M-4. The high binding affinity, promoting a stable and extendable molecular assembly in aqueous solution, could open new frontiers in the design and synthesis of higher-order supramolecular structures with photofunctional moieties and project their utility in therapeutic applications.

• 出版日期2008-9-4