Differences in heterocycle basicity distinguish homocysteine from cysteine using aldehyde-bearing fluorophores

作者：Barve Aabha; Lowry Mark; Escobedo Jorge O; Huynh Katherine T; Hakuna Lovemore; Strongin Robert M^*

来源：Chemical communications, 2014, 50(60): 8219-8222.

DOI：10.1039/c4cc03527e

We report the detection of homocysteine over cysteine based upon characteristic differences between 5- and 6-membered heterocyclic amines formed upon reaction with aldehyde-bearing compounds. Homocysteine-derived thiazinane-4-carboxylic acids are more basic than cysteine-derived thiazolidines-4-carboxylic acids. Fluorescence enhancement in response to homocysteine is achieved by tuning pH and excitation wavelength.

• 出版日期2014