Development and Application of O-(Trimethylsilyl)aryl Fluorosulfates for the Synthesis of Arynes

作者：Chen, Qiao; Yu, Hongmei; Xu, Zhaoqing^*; Lin, Li; Jiang, Xianxing; Wang, Rui

来源：Journal of Organic Chemistry, 2015, 80(13): 6890-6896.

DOI：10.1021/acs.joc.5b00923

• BENZYNE CLICK CHEMISTRY
• METAL-FREE
• SELECTIVE SYNTHESIS
• CARBON-CARBON
• GENERATION
• INDOLYNE
• ACIDS
• DISTORTIONS
• CYCLIZATION
• AMINATION

A class of o-(trimethylsilyl)aryl fluorosulfates was synthesized by a concise method and successfully used as aryne precursors for the first time. Different trapping agents such as azides, furans, and acyl acetoacetates could successfully react with the aryne precursors under mild conditions with good to excellent yields.

• 出版日期2015-7-3
• 单位兰州大学; 中山大学