Modulation of innate and adaptive immunity by biodegradable nanoparticles

作者：Uto Tomofumi; Akagi Takami; Hamasaki Takayuki; Akashi Mitsuru; Baba Masanori^*

来源：Immunology Letters, 2009, 125(1): 46-52.

DOI：10.1016/j.imlet.2009.05.008

• Nanoparticle
• Adjuvant
• Innate immunity
• Adaptive immunity
• Vaccine

Vaccine strategy needs efficient adjuvants to induce potent antigen-specific immune responses by targeting antigens to antigen presenting cells followed by their functional maturation. In this study, biodegradable poly(gamma-glutamic acid) (gamma-PGA) nanoparticles (NPs) were examined for their immunological activities in mice. Like lipopolysaccharide, gamma-PGA NPs strongly activated spleen dendritic cells (DCs) and induced their cytokine production and costimulatory molecule expression through the nuclear factor-kappa B and mitogen-activated protein kinase signaling pathways. The immunization of mice with ovalbumin-carrying gamma-PGA NPs could induce the antigen-specific and long-lived effector and central memory CD8( ) T cells as well as antibody responses. Thus, gamma-PGA NPs have great potential as an efficient antigen carrier and strong adjuvant to DCs.

• 出版日期2009-6-30