A mild and efficient method for bromination of alcohols using alpha,alpha-dibromo-beta-dicarbonyl compounds as halogen sources

作者：Cui Xiao Meng; Guan Yong Hong; Li Na; Lv Hao; Fu Lin An; Guo Kun; Fan Xiaohui^*

来源：Tetrahedron Letters, 2014, 55(1): 90-93.

DOI：10.1016/j.tetlet.2013.10.120

• Appel reaction
• alpha,alpha-Dibromo-beta-dicarbonyl compound
• Alcohol to bromide
• Triphenylphosphine

Exploration of alpha,alpha-dibromo-beta-dicarbonyl compounds as novel bromine agents for the conversion of alcohols to alkyl bromides under neutral conditions has been achieved. This method can be used for acid-sensitive substrates and allows the bromination of various primary and secondary alcohols to proceed at room temperature within a very short period of time.

• 出版日期2014-1-1
• 单位兰州交通大学