A Reference for Ductus Venosus Blood Flow at 11-13(+6) Weeks of Gestation

作者：Pruksanusak Ninlapa^*; Kor Anantakul Ounjai; Suntharasaj Thitima; Suwanrath Chitkasaem; Hanprasertpong Tharangrut; Pranpanus Savitree; Geater Alan

来源：Gynecologic and Obstetric Investigation, 2014, 78(1): 22-25.

DOI：10.1159/000362273

• Crown-rump length
• Ductus venosus blood flow
• Fetal chromosomal abnormalities

Objective: To establish reference ranges for ductus venosus (DV) blood flow assessment obtained transabdominally at 11-13(+6) weeks of gestation. Methods: A cross-sectional study was conducted on singleton pregnancies with a crown-rump length (CRL) ranging from 45 to 84 mm, normal fetus, and subsequent newborn birth weight appropriate for gestational age. Measurements of DV Doppler variables were performed by experienced sonographers: peak velocity during ventricular systole (S-wave) and diastole (D-wave), nadir during atrial contraction (A-wave), time-averaged maximum velocity (TA(max)), pulsatility index for veins (PIV), and peak velocity index for veins (PVIV). Results: A total of 304 fetuses were included. The mean CRL was 60.7 +/- 7.2 mm (range: 45.9-75.5). The mean nuchal translucency measurement was 1.4 +/- 0.4 mm. The S-wave, D-wave, A-wave, and TA(max) values varied significantly with gestational age (p < 0.05) and regression models were constructed for each variable. The remaining variables, systolic/atrial wave ratio, pre-load index, PVIV, and Ply, did not vary significantly with gestational age within this CRL range. Conclusion: Reference ranges for DV Doppler assessment were established in normal fetuses. These ranges may be a useful tool for evaluation of anueploidy and fetal cardiac function.

• 出版日期2014