Anisotropic Snowman-Like Silver Nanoparticles Synthesized by Caesalpinia sappan Extract and In Vitro Antibacterial Activity

作者：Lee You Jeong; Park Youmie

来源：Journal of Nanoscience and Nanotechnology, 2018, 18(6): 3880-3887.

DOI：10.1166/jnn.2018.15210

• Snowman-Like Silver Nanoparticles
• Caesalpinia sappan
• In Vitro Antibacterial Activity
• Cetyltrimethylammonium Bromide
• Staphylococcus aureus

Anisotropic snowman-like silver nanoparticles (AgNPs) were synthesized using the extract of Caesalpinia sappan heartwood as a reducing agent in the presence of cetyltrimethylammonium bromide. Two surface plasmon resonance bands of the orange solution were observed at 446 nm and 539 nm in UV-visible spectra. High-resolution X-ray diffraction analysis confirmed the face-centered cubic structure of the AgNPs. High-resolution transmission electron microscopy images clearly revealed snowman-like AgNPs with an average size of 34.36 +/- 11.44 nm. The C-O functional group was most likely involved in the synthesis of the AgNPs, which was demonstrated by Fourier transform infrared spectra. Most interestingly, the snowman-like AgNPs exhibited higher antibacterial activity than the spherical AgNPs and the extract alone. Among the tested strains, the snowman-like AgNPs showed the highest activity against Staphylococcus aureus, with minimum inhibitory concentrations of 4.69 mu g/mL for the extract and 0.443 mu g/mL for the silver. The antibacterial activity of the snowman-like AgNPs increased 24-fold against S. aureus. These results strongly suggested that the snowman-like AgNPs synthesized from C. sappan extract have potential for treating infected disease caused by S. aureus when the antibacterial activity was combined from plant extract and AgNPs. To our knowledge, the present report is the first in which the snowman-like AgNPs synthesized using a plant extract as a reducing agent showed excellent in vitro antibacterial activity.

• 出版日期2018-6