Postischemic mild hypothermia alleviates hearing loss because of transient ischemia

作者：Takeda Shoichiro; Hakuba Nobuhiro^*; Yoshida Tadashi; Fujita Kensuke; Hato Naohito; Hata Ryuji; Hyodo Jun; Gyo Kiyofumi

来源：NeuroReport, 2008, 19(13): 1325-1328.

DOI：10.1097/WNR.0b013e32830b5f73

• cochlear ischemia
• hair cell loss
• hearing loss
• mild hypothermia

The effect of postischemic mild hypothermia on the inner ear has not been clarified. In this study, we investigated whether hypothermia after transient ischemia could prevent cochlear damage and its therapeutic time Mongolian gerbils were divided into six groups: a sham-operation group, a normothermia group, and four hypothermia groups in which hypothermia was induced 1-7, 1-4, 36, and 6-9 h after reperfusion. Animals subjected to postischemic mild hypothermia within 3 h after reperfusion had attenuated hearing loss and inner hair cell loss. The protective effect was greater when hypothermia was induced earlier and had a longer duration. This implies that mild hypothermia after ischemia could have therapeutic effects for inner ear ischemic damage.

• 出版日期2008-8-27