A general approach for sample size and power calculations based on the Haseman-Elston method

作者：Haeducke Oliver; Pahlke Friedrich; Ziegler Andreas^*

来源：Biometrical Journal, 2008, 50(2): 257-269.

DOI：10.1002/bimj.200710404

• haseman-elston method
• linkage analysis
• power calculations
• quantitative trait
• sample size calculations

Risch and Zhang (1995; Science 268: 1584-9) reported a simple sample size and power calculation approach for the Haseman-Elston method and based their computations on the null hypothesis of no genetic effect. We argue that the more reasonable null hypothesis is that of no recombination. For this null hypothesis, we provide a general approach for sample size and power calculations within the Haseman-Elston framework. We demonstrate the validity of our approach in a Monte-Carlo simulation study and illustrate the differences using data from published segregation analyses on body weight and heritability estimates on carotid artery artherosclerotic lesions.

• 出版日期2008-4
• 单位河北医科大学