Anti-adult T-cell leukemia effects of Bidens pilosa

作者：Nakama Shinji; Ishikawa Chie; Nakachi Sawako; Mori Naoki^*

来源：International Journal of Oncology, 2011, 38(4): 1163-1173.

DOI：10.3892/ijo.2011.939

• adult T-cell leukemia
• human T-cell leukemia virus type 1
• B. pilosa
• NF-kappa B
• AP-1

We evaluated the effects of Bidens pilosa, a plant found in tropical and subtropical regions, and investigated the molecular pathways responsible for the anti-adult T-cell leukemia (ATL) effect. Water extracts of B. pilosa had growth suppressive effects on human T-cell leukemia virus type I (HTLV-1)-infected T-cell lines and ATL cells. B. pilosa extracts arrested cells in G, cell cycle and induced apoptosis of HTLV-1-infected T-cell lines. B. pilosa extracts inhibited also the phosphorylation of I kappa B kinase beta and I kappa B alpha, and NF-kappa B-DNA binding, in conjunction with reduction of expression of proteins involved in G(1)/S cell cycle transition and suppression of apoptosis. Reactive oxygen species played a role in B. pilosa-mediated suppression of NF-kappa B activity. B. pilosa extracts also inhibited the expression of JunB and JunD, resulting in suppression of AP-1-DNA binding. In animals harboring tumors of HTLV-1-infected T-cell origin, treatment with B. pilosa extracts suppressed tumor growth. Our results suggest that B. pilosa is a potentially useful medicinal plant for treatment of ATL.

• 出版日期2011-4