科研之友
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摘要
A new convenient method for the synthesis of oxazolidinone antibacterials Linezolid and Eperezolid from readily available (S)-glyceraldehyde acetonide was developed. The key steps include reductive amination of arylamine and (S)-glyceraldehyde acetonide in the presence of NaBH4 and 4 angstrom sieve, followed by hydrolysis and regioselective cyclization.
- 出版日期2008
- 单位中国科学院; 上海材料研究所; 湖南师范大学
