Adaptive immune features of natural killer cells

作者：Sun Joseph C; Beilke Joshua N; Lanier Lewis L^*

来源：Nature, 2009, 457(7229): 557-561.

DOI：10.1038/nature07665

In an adaptive immune response, naive T cells proliferate during infection and generate long- lived memory cells that undergo secondary expansion after a repeat encounter with the same pathogen. Although natural killer (NK) cells have traditionally been classified as cells of the innate immune system, they share many similarities with cytotoxic T lymphocytes. We use a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection. After a contraction phase, Ly49H- positive NK cells reside in lymphoid and non- lymphoid organs for several months. These self- renewing 'memory' NK cells rapidly degranulate and produce cytokines on reactivation. Adoptive transfer of these NK cells into naive animals followed by viral challenge results in a robust secondary expansion and protective immunity. These findings reveal properties of NK cells that were previously attributed only to cells of the adaptive immune system.

• 出版日期2009-1-29