In Vivo Kinetics of the Uremic Toxin P-Cresyl Sulfate in Mice With Variable Renal Function

作者：Ni, Jingwei; Zhang, Wenli; Zhu, Zhengbin; Zhu, Jinzhou; Du, Run; Jing, Yajun; Lu, Lin; Zhang, Ruiyan^*

来源：Therapeutic Apheresis and Dialysis, 2014, 18(6): 637-642.

DOI：10.1111/1744-9987.12185

• Kinetics
• mouse model
• P-cresyl sulfate
• Uremic toxins

Uremic toxins such as p-cresyl sulfate (PCS) are associated with increased mortality for chronic kidney disease (CKD) patients, but in vivo PCS toxicity studies are limited due to the lack of a standard animal model. To establish such a model, we measured the pharmacokinetics of PCS in mice with variable renal function. Male Balb/c mice subjected to 5/6 nephrectomy (CRF), unilateral nephrectomy (UNX), or no surgery (controls) were given PCS (po, 50mg/kg). Blood samples were collected over time and plasma PCS concentrations were measured. Over 4h, PCS was significantly higher in the plasma of CRF mice (63.28 +/- 2.76mg/L), compared to UNX mice (3.11 +/- 0.64mg/L) and controls (0.39 +/- 0.12mg/L). The PCS half-life was greatest in CRF mice (12.07 +/- 0.12h), compared to 0.79 +/- 0.04h in UNX mice and 0.48 +/- 0.02h in control mice. However, the potential presence of additional uremic toxins along with PCS in CRF mice and rapid PCS clearance in control mice suggest that the UNX mouse would be a better PCS model to study toxicity.

• 出版日期2014-12
• 单位上海市闵行区中心医院; 上海交通大学