Antifungal activity of posaconazole against Candida spp. and non-Candida clinical yeasts isolates

作者：Javier Carrillo Munoz Alfonso; Tur Tur Cristina; Hernandez Molina Juan M; Quindos Guillermo; Marcos Arias Cristina; Eraso Elena; Cardenes Delia; Ortiz Maestro Oscar; Santos Patricia; Estivill Dolors; Guardia Celia; Giusiano Gustavo

来源：Revista Espanola de Quimioterapia, 2010, 23(3): 122-125.

• Antifungal agent
• susceptibility
• posaconazole
• yeasts
• Candida
• Cryptococcus
• Rhodotorula

The in vitro antifungal activity of posaconazole was tested against 315 yeast clinical isolates and 11 ATCC reference strains by means an agar diffusion method (Neosensitabs, Rosco, Denmark) based in CLSI M44-A2 Posaconazole activity was excellent against Cryptococcus and Rhodotorula species studied and showed very good activity against most species of Candida tested. A total of 13 clinical isolates (4.1%) were resistant: Candida albicans (n=5), Candid, glabrata (n=5), Candida tropicalis (n=1), Geotrichum australiensis (n=1) and Geotrichum capitatum (n=1). Our results suggest posaconazole is an effective antifungal agent against the most clinically important yeasts species (92.7% of susceptibility). Agar diffusion method provides good conditions for the posaconazole susceptibility study in the routine laboratory.

• 出版日期2010-9