Action potentials of HL-1 cells recorded with silicon nanowire transistors

作者：Eschermann Jan Felix; Stockmann Regina; Hueske Martin; Vu Xuan Thang; Ingebrandt Sven; Offenhaeusser Andreas

来源：Applied Physics Letters, 2009, 95(8): 083703.

DOI：10.1063/1.3194138

• cellular biophysics
• elemental semiconductors
• nanowires
• silicon
• transistors

Silicon nanowire (NW) transistors were fabricated in a top-down process. These devices were used to record the extracellular potential of the spontaneous activity of cardiac muscle HL-1 cells. Their signals were measured by direct dc sampling of the drain current. An improved signal-to-noise ratio compared to planar field-effect devices was observed. Furthermore the signal shape was evaluated and could be associated to different membrane currents. With these experiments, a qualitative description of the properties of the cell-NW contact was obtained and the suitability of these sensors for electrophysiological measurements in vitro was demonstrated.

• 出版日期2009-8-24